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Two cases of acquired haemophilia A associated with chronic myelomonocytic leukaemia

Noppacharn Uaprasert1, Supakanya Wongrakpanich, Ponlapat Rojnuckarin

  • 1Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand. drnoppacharn@yahoo.com

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|April 11, 2013
PubMed

Acquired haemophilia A (AHA) is an uncommon, but potentially fatal, bleeding diathesis caused by autoantibodies against circulating coagulation factor VIII (FVIII). The incidence is approximately 0.15 cases per 100 000 person-years. The underlying causes of AHA can be identified in approximately half of the patients, of which malignancies account for 10-20%. Heretofore, there has been only one case report of AHA concomitant with chronic myelomonocytic leukaemia (CMMoL), which previously was a subtype of the myelodysplastic syndrome. In this article, we report two more cases of AHA with CMMoL in our hospital and review possible causal relations between these two rare blood disorders.

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