Effect of bone marrow transplantation on diastolic function indices

Area of Science:

• Cardiology
• Oncology
• Transplantation Medicine

Background:

• High-dose chemotherapy and bone marrow transplantation (BMT) can adversely affect cardiac function.
• While chemotherapy's impact on diastolic function is known, BMT's effects are less understood.
• This study investigates cardiac diastolic function changes post-BMT.

Purpose of the Study:

• To evaluate alterations in cardiac diastolic function before and after autologous bone marrow transplantation (BMT).
• To assess the impact of BMT on left ventricular and right ventricular diastolic parameters.

Main Methods:

• Prospective study involving patients undergoing autologous BMT for lymphoma, multiple myeloma, or solid tumors.
• Cardiac consultation and tissue Doppler echocardiography were performed pre- and post-BMT.
• Measured parameters included E-wave velocity and time to relaxation in multiple left ventricular walls and the right ventricle.

Main Results:

• Thirty patients completed the study.
• Significant decreases were observed in E-wave velocity across all measured left ventricular walls post-BMT (19.2% to 7.5%, p<0.05 for most).
• Time to relaxation significantly prolonged in all LV walls post-BMT (11.1% to 13.7%, p<0.001). Right ventricular E-wave velocity also decreased by 15.6% (p=0.02).

Conclusions:

• Diastolic function is significantly altered after bone marrow transplantation.
• The study provides evidence of impaired left and right ventricular diastolic function post-BMT.
• Further research is needed to understand the clinical implications of these diastolic changes.