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Updated: May 12, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Acute generalized exanthematous pustulosis induced by etanercept: another dermatologic adverse effect
Mukaddes Kavala1, Ilkin Zindancı, Zafer Türkoglu
1Department of Dermatology, Istanbul Medeniyet University, SB Istanbul Goztepe Training and Research Hospital, 34732 Istanbul, Turkey.
Abstract:
Acute generalized exanthematous pustulosis (AGEP) is a skin eruption that is primarily drug induced and characterized by the formation of numerous acute and sterile pustules on an erythematous background as mentioned by Weinblatt et al. (1999). We present a case of AGEP, following administration of etanercept, an antitumour necrosis factor alpha (TNF- α ) antibody, in a patient with psoriasis. Recognition of this reaction pattern is important given the frequent reliance on etanercept in treating psoriasis.
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