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Prophylactic drugs for malaria: why do we need another one?

¹Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, The Toronto Hospital, University of Toronto,Toronto, Canada.

Journal of Travel Medicine

|April 11, 2013

Summary

New malaria prevention drugs are needed for travelers. A new scoring system suggests atovaquone/proguanil and WR 238605 may offer better options for malaria chemoprophylaxis.

Area of Science:

Travel Medicine
Infectious Diseases
Pharmacology

Background:

Limited malaria prevention drug options exist for travelers.
Current malaria chemoprophylaxis regimens are not ideal for all individuals.
There is an urgent need for more efficacious and better-tolerated malaria prevention strategies.

Purpose of the Study:

To evaluate new antimalarial agents for traveler chemoprophylaxis.
To develop a decision-making tool for selecting malaria prevention regimens.
To compare the efficacy, tolerance, and safety of different malaria prevention drugs.

Main Methods:

Development of a Clinical Utility Score to assess drug regimens.
Estimation of drug attributes including efficacy, tolerance, convenience, and cost.

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Comparison of new agents (atovaquone/proguanil, WR 238605) with existing options.

Main Results:

New agents like atovaquone/proguanil and WR 238605 show favorable comparisons to current malaria prevention drugs.
The Clinical Utility Score can help tailor malaria prevention to individual traveler needs.
Efficacy may be weighted more heavily than cost or convenience in high-risk areas.

Conclusions:

Atovaquone/proguanil and WR 238605 show promise for malaria chemoprophylaxis in travelers.
The Clinical Utility Score facilitates informed decision-making for malaria prevention.
Further research and clinical experience are needed to optimize malaria prevention strategies for travelers.