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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: May 12, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Inflammation in atherothrombotic disease.

Philippe L L'Allier1

  • 1Department of Medicine, Montreal Heart Institute, University of Montreal, 5000 Belanger East, Montreal, QC H1T IC8, Canada. Philippe.lallier@sympatico.ca

The Journal of Invasive Cardiology
|April 12, 2013
PubMed
Summary

Vascular inflammation is central to atherosclerosis, a systemic disease. Targeting inflammation offers a promising new therapeutic strategy for cardiovascular risk reduction.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pathophysiology

Background:

  • Atherosclerosis is a systemic vascular disease where inflammation is a critical factor.
  • Inflammation is implicated throughout all disease stages, from asymptomatic development to clinical events.

Purpose of the Study:

  • To highlight the pivotal role of vascular inflammation in atherosclerosis.
  • To underscore the predictive value of inflammatory mediators for cardiovascular risk.
  • To discuss emerging anti-inflammatory therapies for atherosclerosis treatment.

Main Methods:

  • Review of epidemiologic evidence linking inflammatory mediators to cardiovascular risk.
  • Analysis of the role of inflammation in atherosclerosis progression.
  • Examination of current research on novel anti-inflammatory drugs.

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On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Related Experiment Videos

Last Updated: May 12, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Main Results:

  • C-reactive protein, an inflammatory mediator, independently predicts cardiovascular risk.
  • Inflammation is a key driver of atherosclerosis from initiation to manifestation.
  • Investigational drugs targeting inflammation show potential for modifying disease course.

Conclusions:

  • Vascular inflammation is a fundamental aspect of atherosclerosis.
  • Inflammatory markers are significant predictors of cardiovascular events.
  • Targeting inflammation represents a promising future therapeutic avenue for managing atherosclerosis.