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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Developments in microarray technologies.

David N Howbrook1, Anne M van der Valk, Meg C O'Shaughnessy

  • 1School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK.

Drug Discovery Today
|April 12, 2013
PubMed
Summary

Microarray technology is advancing drug discovery by enabling high-throughput screening of proteins and small molecules. This progression from genomics to proteomics and beyond offers enhanced information extraction from minimal samples.

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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
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Published on: November 13, 2017

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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
09:27

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Area of Science:

  • Biotechnology and Pharmaceutical Sciences
  • Molecular Biology and Genomics
  • Chemical Biology

Background:

  • High-throughput drug discovery has evolved from analyzing the genome and transcriptome to addressing complex challenges in the proteome, glycome, and metabolome.
  • Microarrays are a key technology for gene expression analysis (cDNA or RNA) and are increasingly utilized for screening protein and small molecule libraries.

Purpose of the Study:

  • To highlight the role and evolution of microarray technology in accelerating the drug discovery process.
  • To discuss the expansion of microarray applications into proteomic, glycomic, and metabolomic analyses.
  • To emphasize the potential of microarrays to enhance efficiency and reduce costs in drug discovery assays.

Main Methods:

  • Utilizes cDNA or RNA analysis for gene expression assessment.
  • Employs screening of protein and small molecule libraries.
  • Leverages miniaturization for increased information yield from small sample volumes.

Main Results:

  • Microarrays have successfully enabled the extraction of more data from reduced sample sizes.
  • The incorporation of low-cost, high-throughput assays has been facilitated by microarray technology.
  • The technology is rapidly adapting to more complex biological systems, including proteomic and glycomic assessments.

Conclusions:

  • Microarray technology is a critical tool driving innovation in high-throughput drug discovery.
  • The ongoing development of specialized arrays (proteomic, glycomic, tissue) promises further advancements.
  • Microarrays significantly enhance the efficiency and scope of the drug discovery pipeline.