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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
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Intact protein mass spectrometry and top-down proteomics

Julian Whitelegge1

  • 1The Pasarow Mass Spectrometry Laboratory, UCLA, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095, USA. jpw@chem.ucla.edu

Expert Review of Proteomics
|April 12, 2013
PubMed
Summary

Top-down mass spectrometry analyzes intact proteins for enhanced identification. Advances in instrumentation and informatics are driving this precision technology toward high-throughput proteomics applications.

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