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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
Hydroxychloroquine-induced phospholipidosis in a case of SLE: the wolf in zebra clothing
Shaila Raju Khubchandani1, Lata Sunil Bichle
1Jaslok Hospital and Research Center, Histopathology, Mumbai, India. shailakhubchandani@yahoo.co.in
Abstract:
A 30 year old lady patient of SLE on steroid and hydroxychloroquine therapy presented with lupus nephritis and later developed cardiac symptoms. Her renal biopsy revealed features of Class III lupus nephritis. Also seen was typical lamellated myelinoid material in the glomerulus. The alpha-galactosidase A activity was normal. The clinical morphological and biochemical findings were consistent with Lupus nephritis showing changes of hydroxychloroquine induced phopholipidosis. Electron microscopy along with careful clinical examination and follow up status was instrumental in the diagnosis of the latter.
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