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Related Concept Videos

Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
Significant Figures in Calculations00:58

Significant Figures in Calculations

Uncertainty in measurements can be avoided by reporting the results of a calculation with the correct number of significant figures. This can be determined by the following rules for rounding numbers:
Numerical Calculations01:24

Numerical Calculations

In engineering applications, the representation of the numerical value is critical. Presenting or reporting the answer is one of the essential parts of engineering practices. Numerical calculations are performed using handheld calculators or computers since numerically accurate answers are always preferred.
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Downsampling01:20

Downsampling

When considering a sampled sequence with zero values between sampling instants, one can replace it by taking every N-th value of the sequence. At these integer multiples of N, the original and sampled sequences coincide. This process, known as decimation, involves extracting every N-th sample from a sequence, thereby creating a more efficient sequence.
The Fourier transform of the decimated sequence reveals a combination of scaled and shifted versions of the original spectrum. This...
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Uncertainty in Measurement: Significant Figures03:34

Uncertainty in Measurement: Significant Figures

All the digits in a measurement, including the uncertain last digit, are called significant figures or significant digits. Note that zero may be a measured value; for example, if a scale that shows weight to the nearest pound reads “140,” then the 1 (hundreds), 4 (tens), and 0 (ones) are all significant (measured) values.

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Related Experiment Video

Updated: May 12, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Redefining the number needed to excise.

Lucy Chen1, Stephen Dusza, Marta Grazzini

  • 1Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

The Australasian Journal of Dermatology
|April 12, 2013
PubMed
Summary
This summary is machine-generated.

The number needed to excise (NNE) metric should assess all skin cancer types, not just melanoma. Data from two sites show NNE trends over time, highlighting its utility in dermatological practice for diagnostic accuracy.

Keywords:
dermoscopymelanomanumber need to exciseskin cancer

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Area of Science:

  • Dermatology
  • Surgical Oncology
  • Public Health

Background:

  • The number needed to excise (NNE) is a metric evaluating diagnostic accuracy in dermatology.
  • Current NNE calculations often focus solely on melanoma, potentially limiting a comprehensive assessment of practice efficiency.

Observation:

  • This study evaluated NNE across all skin cancer types, not exclusively melanoma.
  • Data were collected from two distinct clinical sites to capture broader trends.

Findings:

  • The NNE metric demonstrates utility when applied to all skin cancer types.
  • Analysis revealed specific trends in NNE over time, indicating shifts in diagnostic efficiency.

Implications:

  • Expanding NNE to include all skin cancers provides a more robust measure of dermatological practice efficiency.
  • Understanding NNE trends can inform targeted improvements in diagnostic strategies and resource allocation for skin cancer management.