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Related Experiment Video

Updated: May 12, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Neuropeptide systems and schizophrenia.

Amber L LaCrosse¹, M Foster Olive

¹Department of Psychology, Arizona State University, 950 S. McAllister Ave, PO Box 871104, Tempe, AZ 85287-1104, USA. alacross@asu.edu

CNS & Neurological Disorders Drug Targets

|April 12, 2013

Summary

Neuropeptides, co-released with neurotransmitters, modulate brain function and behaviors related to schizophrenia. Targeting neuropeptide systems offers potential for novel antipsychotic drug development.

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Schizophrenia impacts ~1% of the global population.
Current treatments primarily target monoaminergic systems.
Neuropeptides are co-released with monoamines and modulate their transmission.

Purpose of the Study:

To review the role of neuropeptide systems in schizophrenia.
To explore neuropeptide receptor ligands as potential antipsychotics.

Main Methods:

Literature review of preclinical and clinical studies.
Analysis of neuropeptide systems including neurotensin, CCK, CRF, NPY, oxytocin, opioids, tachykinins, TRH, and orexins.

Main Results:

Neuropeptide systems significantly modulate monoaminergic transmission.
Neuropeptide receptor ligands show promise in preclinical models of schizophrenia-related behaviors.

Conclusions:

Neuropeptide systems represent a promising avenue for novel antipsychotic drug discovery.
Targeting specific neuropeptide pathways could lead to more effective schizophrenia treatments.