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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: May 12, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Promoting transplantation tolerance; adoptive regulatory T cell therapy.

N Safinia1, J Leech, M Hernandez-Fuentes

  • 1MRC Centre for Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Clinical and Experimental Immunology
|April 12, 2013
PubMed
Summary

Regulatory T cells (Tregs) show promise for inducing transplantation tolerance, minimizing immunosuppression. Early clinical trials in hematopoietic stem cell transplantation demonstrate their potential in preventing graft-versus-host disease (GVHD).

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Last Updated: May 12, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

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Published on: May 2, 2013

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Cellular Therapy

Background:

  • Organ transplantation is a vital treatment for end-stage organ failure.
  • Long-term transplant survival is limited by immunosuppression-related complications.
  • Minimizing or withdrawing immunosuppression is crucial for improving patient outcomes.

Purpose of the Study:

  • To review the role of regulatory T cells (Tregs) in promoting transplantation tolerance.
  • To explore the potential of Tregs as a cellular therapy to reduce immunosuppression.
  • To discuss current clinical applications and future directions of Treg-based therapies.

Main Methods:

  • Review of preclinical data on Treg function in immune tolerance.
  • Analysis of data from early clinical trials using Tregs.
  • Discussion of challenges and opportunities in human Treg cell therapy.

Main Results:

  • Preclinical studies highlight Tregs' importance in inducing and maintaining immune tolerance.
  • Early clinical trials show Tregs can inhibit graft-versus-host disease (GVHD) post-hematopoietic stem cell transplantation.
  • Treg isolation and expansion are feasible for cellular therapy applications.

Conclusions:

  • Regulatory T cells (Tregs) represent a promising strategy for inducing transplantation tolerance.
  • Treg cell therapy offers a potential avenue to minimize long-term immunosuppression in transplant recipients.
  • Further research and clinical trials are needed to optimize Treg therapy for broader transplantation applications.