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Related Experiment Video

Updated: May 12, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium

Published on: May 31, 2024

Gastric pouch interposition between ileum and anus after total proctocolectomy.

Rat¹, Cheynel, Benoit

¹Service de Chirurgie Digestive,Thoracique et Cancérologique, C.H.U. de Dijon, France.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland

|April 12, 2013

Summary

A novel surgical technique uses a stomach pouch to avoid permanent ileostomy after proctocolectomy for Crohn's disease (CD). This method offers satisfactory functional results, though proton pump inhibitors are needed to manage anal burning.

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Area of Science:

Gastroenterology
Surgical Innovation
Colorectal Surgery

Background:

Ileal pouch-anal anastomosis is often not feasible after proctocolectomy for familial adenomatous polyposis or ulcerative colitis.
Crohn's disease (CD) generally contraindicates ileal pouch-anal anastomosis, frequently necessitating a permanent ileostomy.

Purpose of the Study:

To present a surgical technique to avoid permanent ileostomy in patients with Crohn's disease undergoing proctocolectomy.
To evaluate the feasibility and functional outcomes of this novel reconstructive approach.

Main Methods:

A surgical procedure involving the transposition of the left half of the stomach's vertical portion as a vascularized pouch (right gastroepiploic pedicle) between the ileum and anus.
Application of this technique in a 35-year-old female patient post-proctocolectomy for CD.

Main Results:

Successful implementation of the stomach pouch transposition without post-operative complications.
Satisfactory functional outcomes at 9 months, including 2-5 stools/24h, absence of urgency, and minimal nocturnal seepage.
Requirement for high-dose proton pump inhibitor therapy to mitigate anal burning sensation.

Conclusions:

This stomach pouch transposition offers a viable alternative to permanent ileostomy in select cases of proctocolectomy for Crohn's disease.
The procedure demonstrates good functional results but necessitates management of potential side effects like anal burning.