Related Experiment Video
Updated: May 12, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Outpatient parenteral antimicrobial therapy: its delivery in the community
1Ealing Hospital Trust. linda@nazarko.co.uk
Insights
Outpatient parenteral antimicrobial therapy (OPAT) is increasingly common, with nearly 70% of suitable inpatients now candidates. Services are evolving to meet demand, focusing on models, setup, and staff development for effective delivery.
Area of Science:
- Infectious Diseases
- Healthcare Management
- Pharmacology
Background:
- Outpatient parenteral antimicrobial therapy (OPAT) suitability has significantly increased from a minority 15 years ago to nearly 70% of inpatients.
- A substantial proportion, 38-53%, of patients requiring OPAT can self-administer the therapy.
- There is a growing demand for intravenous antimicrobial therapy, necessitating changes in its delivery models.
Purpose of the Study:
- To examine current service models for outpatient parenteral antimicrobial therapy (OPAT).
- To provide guidance on establishing and developing staff for OPAT services.
- To address the evolving landscape of intravenous antimicrobial therapy delivery.
Main Methods:
- Review of existing literature and service models for OPAT.
- Analysis of factors influencing patient suitability and self-administration rates.
- Discussion of best practices for OPAT service implementation and staff training.
Main Results:
- Significant increase in patient suitability for OPAT over the past 15 years.
- High percentage of patients capable of self-administering OPAT.
- Identification of key elements for successful OPAT service delivery.
Conclusions:
- OPAT services are becoming a mainstream component of antimicrobial therapy.
- Effective service models and trained staff are crucial for expanding OPAT.
- The trend indicates a shift towards more community-based antimicrobial treatments.
Abstract:
Fifteen years ago, only a small minority of hospital inpatients were considered suitable for outpatient parenteral antimicrobial therapy (OPAT) services (Wiselka and Nicholson, 1997). Now almost 70% of those treated with intravenous antibiotics as hospital inpatients are considered suitable (Hitchcock et al, 2009). In total, 38-53% percent of those requiring OPAT are able to self-administer (Hills et al, 2012). The demand for intravenous antimicrobial therapy is increasing and the way it is being delivered is changing. This article examines service models, setting up services and developing staff to enable them to deliver OPAT services.
Related Concept Videos
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
