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Updated: May 12, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
[Outcome for pulmonary metastases from malignant osteogenic and soft tissue sarcomas]
Hironori Tempaku1, Motoshi Takao, Akira Shimamoto
1Department of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Tsu, Japan.
Abstract:
We reviewed outcome for pulmonary metastases from malignant osteogenic and soft tissue sarcomas. From January 2001 to December 2010, 43 patients with pulmonary metastases from malignant osteogenic and soft tissue sarcomas were treated. Twenty-four were male and 19 were female. Age ranged 12~86 (median 47.3) years. Operations were performed in 12 cases (group O), radiofrequency ablations were performed in 16 cases (group R), and both were performed in 13 cases (group OR). Overall 5-year survival rate was 24.5%. The 5-year survival was 50.2% for patients with a disease-free interval of more than 12 months and 6.1% for those with a disease-free interval of less than 12 months. There was significant difference in cases of bilateral pulmonary metastases between the group O and the other 2 groups. There was significant difference in the numbers of treated lesions between the group OR and the other 2 groups. There was no difference in overall survival among the 3 groups. These results might suggest that the hybrid therapy of operation and radiofrequency ablation improves the prognosis of patients with pulmonary metastases from malignant osteogenic and soft tissue sarcomas.

