Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoreactive interleukin-1 beta localization in the rat forebrain.

R M Lechan1, R Toni, B D Clark

  • 1Department of Medicine, New England Medical Center, Boston, MA 02111.

Brain Research
|April 23, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recruitment of Older African Americans in Alzheimer's Disease Clinical Trials Using a Community Education Approach.

The journal of prevention of Alzheimer's disease·2022
Same author

Representation of Racial and Ethnic Minority Populations in Dementia Prevention Trials: A Systematic Review.

The journal of prevention of Alzheimer's disease·2022
Same author

MR Imaging Features of Middle Cranial Fossa Encephaloceles and Their Associations with Epilepsy.

AJNR. American journal of neuroradiology·2020
Same author

Feeding postures of suspension-feeding larval black flies: the conflicting demands of drag and food acquisition.

Oecologia·2017
Same author

Bone loss from high repetitive high force loading is prevented by ibuprofen treatment.

Journal of musculoskeletal & neuronal interactions·2014
Same author

Performance of a repetitive task by aged rats leads to median neuropathy and spinal cord inflammation with associated sensorimotor declines.

Neuroscience·2010

Interleukin-1 beta (IL-1 beta) is present in the rat brain, forming a neural system. This cytokine is found in brain regions controlling autonomic, limbic, and other key functions.

Area of Science:

  • Neuroscience
  • Immunology
  • Cytokine Research

Background:

  • Interleukin-1 beta (IL-1 beta) is a cytokine known to be present in the human brain.
  • Its presence and role in the rat central nervous system (CNS) have not been fully elucidated.

Purpose of the Study:

  • To investigate the presence and localization of interleukin-1 beta (IL-1 beta) in the rat brain.
  • To determine if IL-1 beta is part of an intrinsic neural system within the rat CNS.

Main Methods:

  • Immunocytochemical studies were conducted on rat brain tissue.
  • A specific antiserum recognizing recombinant rat IL-1 beta was utilized for detection.

Main Results:

  • Immunoreaction product for IL-1 beta was observed in specific rat brain regions.

Related Experiment Videos

  • Detected areas include the periventricular and medial hypothalamus, hippocampus (mossy fiber distribution), and olfactory tubercle.
  • These findings suggest IL-1 beta is distributed within a diffuse intrinsic neural system.

    • Conclusions:

    • Interleukin-1 beta (IL-1 beta) is demonstrably present in the rat central nervous system.
    • IL-1 beta is associated with neural regions involved in hypophysiotropic, autonomic, limbic, and extrapyramidal functions.
    • The cytokine appears to be an integral component of a diffuse neural network in the rat brain.