Related Experiment Video
Updated: May 12, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
[A man with erythema and pustules].
Christy E van Drie1, Maybritt I Kuypers
1Westfriesgasthuis, afd. Spoedeisende Geneeskunde, Hoorn, the Netherlands. c.e.vandrie@amc.uva.nl
Nederlands Tijdschrift Voor Geneeskunde
|April 12, 2013
Summary
A man developed acute generalized exanthematous pustulosis (AGEP) after taking amoxicillin/clavulanic acid. Symptoms resolved after discontinuing the antibiotic medication.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Drug-induced hypersensitivity reactions are a significant concern in clinical practice.
- Amoxicillin/clavulanic acid is a commonly prescribed antibiotic with a known potential for adverse effects.
Observation:
- A 47-year-old male presented with a sudden, widespread rash and pustules.
- The onset of symptoms occurred shortly after initiating amoxicillin/clavulanic acid for a pulmonary infection.
Findings:
- Clinical presentation and histopathological examination confirmed the diagnosis of acute generalized exanthematous pustulosis (AGEP).
- Cessation of amoxicillin/clavulanic acid led to the gradual resolution of the skin abnormalities.
Implications:
- This case highlights the importance of considering AGEP in patients presenting with pustular eruptions post-antibiotic initiation.
- Early recognition and drug withdrawal are crucial for managing amoxicillin/clavulanic acid-induced AGEP.
- Awareness of potential adverse drug reactions is vital for patient safety and effective treatment strategies.
Related Concept Videos
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:19Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...