Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The two phases of the clinical validation of preclinical translational mechanistic research on PDE5 inhibitors since Viagra's advent. A personal perspective.

International journal of impotence research·2018
Same author

Myostatin, a profibrotic factor and the main inhibitor of striated muscle mass, is present in the penile and vascular smooth muscle.

International journal of impotence research·2017
Same author

Oral Bisphenol A (BPA) given to rats at moderate doses is associated with erectile dysfunction, cavernosal lipofibrosis and alterations of global gene transcription.

International journal of impotence research·2013
Same author

Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial.

Arthritis and rheumatism·2010
Same author

Neck mass in a rheumatoid arthritis patient taking etanercept.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

Discovery of NO in the penis.

International journal of impotence research·2008
Same journal

Attachment orientation and sexual excitation and inhibition independently predict sexual desire and sexual arousal, but their interaction does not.

International journal of impotence research·2026
Same journal

Comment on: Application of gelatin sponge (Gelfoam®) as a hemostatic agent in inflatable penile prosthesis implantation.

International journal of impotence research·2026
Same journal

It Comes at Night: A Nocturnal Emissions Historical Review.

International journal of impotence research·2026
Same journal

Challenging the paradigm: what is vasculogenic erectile dysfunction?

International journal of impotence research·2026
Same journal

Comment on: GLP-1 receptor agonists and male sexual health: translating cardiometabolic benefits into erectile outcomes.

International journal of impotence research·2026
Same journal

Erectile and ejaculatory outcomes after penile fracture repair: a comparative analysis of absorbable vs non-absorbable sutures.

International journal of impotence research·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Early onset erectile dysfunction is usually not associated with abnormal cavernosal arterial Inflow.

J Rajfer1, J Valeriano, R Sinow

  • 11] Division of Urology, Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA [2] Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA.

International Journal of Impotence Research
|April 12, 2013
PubMed
Summary
This summary is machine-generated.

Arterial disease is not the primary cause of erectile dysfunction (ED) in most young men. A review of ultrasound scans found a low incidence of arterial abnormalities in men under 50 with ED.

Related Experiment Videos

Last Updated: May 12, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Vascular Medicine
  • Urology
  • Cardiovascular Health

Background:

  • Endothelial dysfunction, a marker of atherosclerosis and arterial disease, is increasingly implicated in the development of erectile dysfunction (ED).
  • The role of arterial disease in the early onset of ED, particularly in younger men, requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of arterial disease in young men (under 50 years) presenting with ED.
  • To determine if arterial disease is a primary factor in the etiology of ED in this demographic.

Main Methods:

  • Retrospective review of duplex ultrasound scans.
  • Analysis of arterial responses in 23 men under 50 years of age diagnosed with ED.
  • Assessment based on established criteria for abnormal arterial responses.

Main Results:

  • A low incidence of abnormal arterial responses was observed, ranging from 4% to 13% in the cohort.
  • These findings suggest limited involvement of the penile arterial system in the majority of ED cases among young men.

Conclusions:

  • The penile arterial system is unlikely to be the primary cause of ED in most young men.
  • Alternative etiologies should be considered for ED in younger populations.
  • Further research is needed to understand the multifactorial nature of ED in young men.