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A high-normal thyrotropin level is associated with the severity of left ventricular diastolic dysfunction in patients

Shi Chen1, Jiansong Yuan, Shubin Qiao

  • 1Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Kardiologia Polska
|April 12, 2013
PubMed

Insights

High-normal thyroid-stimulating hormone (TSH) levels are linked to worse left ventricular (LV) diastolic dysfunction in hypertrophic cardiomyopathy (HCM) patients. This suggests TSH may influence heart failure development in HCM.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Left ventricular (LV) diastolic dysfunction is a hallmark of hypertrophic cardiomyopathy (HCM).
  • Elevated thyrotropin (thyroid-stimulating hormone, TSH) levels within the normal range may impact cardiac function.

Purpose of the Study:

  • To investigate the association between increasing TSH levels within the reference range and the severity of LV diastolic dysfunction in HCM patients.

Main Methods:

  • Assessed 152 HCM patients and 119 controls for serum TSH, FT3, and FT4.
  • Quantified LV diastolic function using the E/Ea ratio.
  • Analyzed correlations between TSH levels and diastolic function parameters.

Main Results:

  • HCM patients with high-normal TSH showed significantly higher E/Ea ratios (25.7 ± 5.6 vs. 17.7 ± 4.9, p < 0.001).
  • A significant correlation was found between E/Ea ratio and high-normal TSH levels (β = 0.268, p = 0.021).
  • High-normal TSH predicted severe heart failure in univariate analysis, but not after adjusting for LV diastolic dysfunction.

Conclusions:

  • Hypertrophic cardiomyopathy patients with high-normal TSH levels exhibit increased LV diastolic dysfunction.
  • TSH level variations within the high reference range can exacerbate impaired LV diastolic function.
  • High-normal TSH may contribute to heart failure development in HCM via its association with LV diastolic impairment.
Abstract

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