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Plateletcrit. A platelet marker associated with saphenous vein graft disease

I Akpinar1, M R Sayin, Y C Gursoy

  • 1School of Medicine, Department of Cardiology, Bulent Ecevit University, 67600, Kozlu/Zonguldak, Turkey, dr.ibrahimakpinar@gmail.com.

Herz
|April 12, 2013
PubMed

Insights

Plateletcrit (PCT) can predict saphenous vein graft disease (SVGD) after bypass surgery. Higher PCT levels indicate increased risk, suggesting PCT as a marker for anti-platelet therapy to prevent graft atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biomarker Discovery

Background:

  • Saphenous vein graft disease (SVGD) is a major complication following coronary artery bypass surgery, contributing to patient morbidity and mortality.
  • Limited understanding exists regarding the biochemical and hematological parameters associated with SVGD.
  • Plateletcrit (PCT), a measure of total platelet mass, has not been previously investigated in the context of SVGD.

Purpose of the Study:

  • To investigate the relationship between SVGD and various platelet parameters, including PCT, mean platelet volume, platelet count, and platelet distribution.
  • To determine if PCT can serve as a predictive marker for SVGD.

Main Methods:

  • Retrospective analysis of 14,398 patients undergoing coronary angiography.
  • Focus on 251 patients with prior coronary artery bypass graft operations, divided into SVGD and patent graft groups.
  • Comparison of hematological and biochemical parameters between the two groups.

Main Results:

  • Patients with SVGD had a significantly longer time from surgery to angiography compared to the patent graft group.
  • SVGD group exhibited significantly higher median PCT, mean platelet volume, platelet count, uric acid, and red blood cell distribution width.
  • A PCT cut-off value of 0.188 demonstrated 80.65% sensitivity and 81.1% specificity for predicting SVGD.

Conclusions:

  • Plateletcrit (PCT) demonstrates significant predictive value for identifying saphenous vein graft disease (SVGD).
  • PCT can be utilized as a valuable biomarker for guiding anti-platelet therapy in patients undergoing bypass surgery.
  • Early identification and management of SVGD risk factors, potentially indicated by PCT, can help prevent graft atherosclerosis.
Abstract

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