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Updated: May 12, 2026
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Effect of photodynamic therapy on the skin using the ultrashort laser ablation
Gustavo Nicolodelli1, Dora Patricia Ramírez Angarita, Natalia Mayumi Inada
1Physics Institute of Sao Carlos IFSC, University of Sao Paulo, Biophotonics Laboratory, Sao Carlos-SP, Brazil. gunicolodelli@hotmail.com.
Abstract:
Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA) is known to be limited for applications in tumours of large volume mainly due to the limited penetration of topical photosensitization. The results show that micro-holes created using a femtosecond laser before PDT significantly increased the depth of PDT effect in the healthy tissue. The combination of ultrashort laser ablation technique with PDT showed an important scientific breakthrough related to transportation and delivery of drugs into the deeper regions of the tissue.
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