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Updated: May 12, 2026

Axoplasm Isolation from Rat Sciatic Nerve
Published on: September 24, 2010
Proton hopping: a proposed mechanism for myelinated axon nerve impulses
Lemont B Kier1, Robert M Tombes
1Life Sciences, Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA. lbkier@vcu.edu
Abstract:
Myelinated axon nerve impulses travel 100 times more rapidly than impulses in non-myelinated axons. Increased speed is currently believed to be due to 'hopping' or 'saltatory propagation' along the axon, but the mechanism by which impulses flow has never been adequately explained. We have used modeling approaches to simulate a role for proton hopping in the space between the plasma membrane and myelin sheath as the mechanism of nerve action-potential flow.
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