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Updated: May 12, 2026

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
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The evidence regarding maintenance tocolysis.

John P Elliott1, John C Morrison

  • 1Perinatal Services, Division of Southwest Contemporary Women's Care, Southwest Perinatal Services, 16611 S. 40th Street, Phoenix, AZ 85048, USA.

Obstetrics and Gynecology International
|April 12, 2013
PubMed
Summary
This summary is machine-generated.

Maintenance tocolytic therapy aims to prolong pregnancy after preterm labor arrest. This review examines oral and subcutaneous drug efficacy, safety, and FDA actions impacting their use in the United States.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Pharmacology

Background:

  • Preterm delivery is a significant public health concern, with over 12% of US births occurring before 37 weeks gestation.
  • Preterm labor (PTL) is the primary cause of preterm birth (PTB), and prevention strategies have largely been unsuccessful.
  • Maintenance tocolytic therapy is used to prolong pregnancy after acute preterm labor has been arrested.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral and subcutaneous tocolytic drugs for maintenance therapy.
  • To review the evidence supporting the use of parenteral medications for prolonging pregnancy.
  • To report the impact of Food and Drug Administration (FDA) actions on these medications in the US.

Main Methods:

  • Systematic review of existing literature on maintenance tocolytic therapy.
  • Analysis of clinical trial data and observational studies.
  • Examination of FDA regulatory actions and their consequences.

Main Results:

  • Evidence for the efficacy of oral tocolytics as maintenance therapy is presented.
  • Safety profiles of various oral and subcutaneous tocolytic agents are discussed.
  • The impact of FDA decisions on the availability and use of these drugs is reported.

Conclusions:

  • Maintenance tocolytic therapy remains a critical area of research in managing preterm labor.
  • Further investigation is needed to optimize drug selection and treatment protocols.
  • FDA regulations significantly influence clinical practice and drug accessibility for preterm birth prevention.