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Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: May 12, 2026

In vitro Measurements of Tracheal Constriction Using Mice
10:20

In vitro Measurements of Tracheal Constriction Using Mice

Published on: June 25, 2012

Airway smooth muscle hypercontractility in asthma.

Rachid Berair1, Fay Hollins, Christopher Brightling

  • 1Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester LE3 9QP, UK.

Journal of Allergy
|April 12, 2013
PubMed
Summary

Asthmatic airway smooth muscle (ASM) is intrinsically hypercontractile due to molecular and signaling pathway differences. Targeting these abnormalities offers new therapeutic avenues for severe asthma.

More Related Videos

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle
08:59

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle

Published on: May 5, 2022

Related Experiment Videos

Last Updated: May 12, 2026

In vitro Measurements of Tracheal Constriction Using Mice
10:20

In vitro Measurements of Tracheal Constriction Using Mice

Published on: June 25, 2012

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle
08:59

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle

Published on: May 5, 2022

Area of Science:

  • Pulmonary Medicine
  • Cellular Biology
  • Pharmacology

Background:

  • Asthma is traditionally viewed as an inflammatory disorder.
  • Airway smooth muscle (ASM) dysfunction is key to asthma's airway obstruction.
  • Asthmatic ASM's intrinsic functional properties remain under-explored.

Purpose of the Study:

  • To investigate functional differences in asthmatic ASM.
  • To identify molecular mechanisms underlying asthmatic ASM hypercontractility.
  • To explore novel therapeutic targets for severe asthma.

Main Methods:

  • Analysis of single ASM cells.
  • Studies using ASM-impregnated gel cultures.
  • Investigation of contractile proteins and signaling pathways.
  • Assessment of oxidative stress in ASM.

Main Results:

  • Asthmatic ASM exhibits intrinsic hypercontractility.
  • Differences observed in contractile proteins and signaling pathways (calcium-dependent and independent).
  • Elevated oxidative stress contributes to ASM hypercontractility in asthma.

Conclusions:

  • Asthmatic ASM possesses distinct hypercontractile properties.
  • Understanding these mechanisms is crucial for developing targeted therapies.
  • Novel drugs targeting ASM hypercontractility could address unmet needs in severe asthma.