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Intracranial ependymomas in children.

S Undjian¹, M Marinov

¹Department of Neurosurgery, Medical Academy, Sofia, Bulgaria.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery

|May 1, 1990

Summary

This study on pediatric intracranial ependymomas found that supratentorial tumors had better outcomes than posterior fossa tumors. Improved survival for children with brain tumors depends on radical resection, radiotherapy, and chemotherapy.

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Area of Science:

Pediatric neurosurgery
Pediatric oncology
Central nervous system tumors

Background:

Ependymomas are common primary central nervous system tumors in children.
Intracranial ependymomas present unique challenges in pediatric neurosurgery.
Tumor location significantly impacts clinical presentation and treatment outcomes.

Purpose of the Study:

To analyze the clinical characteristics, treatment outcomes, and survival rates of pediatric intracranial ependymomas.
To compare outcomes between supratentorial and posterior fossa ependymomas in children.
To identify prognostic factors for improving survival in pediatric ependymoma patients.

Main Methods:

Retrospective analysis of 60 pediatric patients with intracranial ependymomas treated between 1964 and 1983.
Categorization of tumors based on location (supratentorial vs. posterior fossa).
Evaluation of surgical resection extent, postoperative mortality, and long-term survival rates.

Main Results:

Posterior fossa ependymomas had shorter clinical evolution and higher incidence of localizing signs compared to supratentorial tumors.
Radical resection rates were low for both locations (21.6% posterior fossa, 30.4% supratentorial).
Postoperative mortality was higher for posterior fossa tumors (29.7%) than supratentorial (17.4%), with lower survival rates.

Conclusions:

Supratentorial ependymomas demonstrated more favorable outcomes than posterior fossa ependymomas in this cohort.
Radical tumor resection, combined with postoperative radiotherapy and chemotherapy, is crucial for improving outcomes.
Further research is needed to optimize treatment strategies for pediatric intracranial ependymomas.

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