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Published on: September 28, 2016
Associations between TNF-α polymorphisms and pneumonia: a meta-analysis.
1Department of Respiratory Medicine, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.
Plos One
|April 12, 2013
Summary
Genetic variations in tumor necrosis factor-alpha (TNF-α) polymorphisms, specifically -308A/G and -238A/G, were not linked to an increased risk of pneumonia. These TNF-α gene variants also showed no association with pneumonia mortality in this meta-analysis.
Area of Science:
- Genetics
- Immunology
- Respiratory Medicine
Background:
- Previous studies have explored the link between tumor necrosis factor-alpha (TNF-α) gene polymorphisms and pneumonia susceptibility.
- However, existing research presents conflicting and controversial findings regarding this association.
Purpose of the Study:
- To systematically evaluate the association between TNF-α gene polymorphisms (-308A/G and -238A/G) and the risk of pneumonia.
- To investigate the role of TNF-α -308A/G polymorphism in pneumonia mortality.
Main Methods:
- A comprehensive literature search was conducted across major databases (PubMed, Embase, Web of Science, CNKI).
- Relevant case-control and cohort studies were identified and data were extracted by two independent investigators.
- Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the associations.
Main Results:
- The meta-analysis included 12 case-control studies and 1 cohort study.
- No significant association was found between TNF-α -308A/G polymorphism and pneumonia risk (OR=1.13; 95% CI 0.99-1.30).
- Furthermore, TNF-α -308A/G and -238A/G polymorphisms were not associated with pneumonia mortality or risk, respectively.
Conclusions:
- The findings indicate that TNF-α -308A/G and -238A/G polymorphisms are not associated with an increased risk of developing pneumonia.
- The TNF-α -308A/G polymorphism does not appear to influence the risk of mortality in pneumonia patients.
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