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Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

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Related Experiment Video

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Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
04:04

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

Thyroid hormone and wound healing.

Joshua D Safer1

  • 1Section of Endocrinology, Boston University School of Medicine, Room M-1016, 715 Albany Street, Boston, MA 02118, USA.

Journal of Thyroid Research
|April 12, 2013
PubMed
Summary
This summary is machine-generated.

Topical thyroid hormone shows promise for treating skin conditions. Studies indicate thyroid hormone accelerates wound healing and hair growth, suggesting potential for various cutaneous pathologies.

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Area of Science:

  • Dermatology
  • Endocrinology
  • Molecular Biology

Background:

  • Thyroid hormone is a potent stimulator of growth and metabolism.
  • The therapeutic potential of topical thyroid hormone for skin conditions remains largely unexplored.
  • Skin manifestations of thyroid disease are well-documented, but direct hormone action on skin cells is less understood.

Purpose of the Study:

  • To review the literature on thyroid hormone's action on skin.
  • To provide context for recent findings on direct thyroid hormone effects on cutaneous cells.
  • To explore the potential of thyroid hormone for treating cutaneous pathologies, particularly wound healing.

Main Methods:

  • Literature review of thyroid hormone action on skin.
  • Review of skin manifestations associated with thyroid disease.
  • Examination of in vitro and in vivo studies on thyroid hormone's direct effects on skin cells.

Main Results:

  • Topical triiodothyronine (T3) accelerated wound healing and hair growth in rodent models.
  • Topical thyroxine (T4) has been utilized in humans to treat xerosis (dry skin).
  • Emerging evidence demonstrates direct thyroid hormone activity on cutaneous cells.

Conclusions:

  • Thyroid hormone holds significant therapeutic potential for treating various skin conditions.
  • Further research into topical thyroid hormone applications, especially for wound healing, is warranted.
  • Understanding thyroid hormone's direct effects on skin cells may unlock novel dermatological treatments.