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Updated: May 12, 2026

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

Optical fiber light source directs neurite growth.

Forrest Jesse¹, Zhenjiang Miao, Li Zhao

¹School of Computer and Information Technology, Beijing Jiaotong University, Beijing, 100044, China ; Department of Sports Physiology, Beijing Sports University, Beijing, 100084, China.

Biomedical Optics Express

|April 12, 2013

Summary

Researchers used focused laser light to guide neurite growth by controlling an optical fiber

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Area of Science:

Neuroscience
Biophysics
Optical Engineering

Background:

Neurite outgrowth is crucial for neural development and repair.
Precise control over neurite guidance is essential for understanding neural circuit formation.
Current methods for neurite guidance lack spatial precision.

Purpose of the Study:

To develop a method for precisely guiding neurite growth using light.
To investigate the effects of light-directed actin accumulation on neurite mobility.

Main Methods:

Utilized a tapered optical fiber to project ~800 nm laser light.
Controlled the three-dimensional position and angle of the optical fiber.
Manipulated laser beam power to influence actin accumulation.

Keywords:

(060.2390) Fiber optics, infrared (140.0140) Lasers and laser optics (170.0170) Medical optics and biotechnology

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Last Updated: May 12, 2026

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

Standardization of a Novel Semi-Automatic Software for Neurite Outgrowth Measurement

Standardization of a Novel Semi-Automatic Software for Neurite Outgrowth Measurement

Published on: August 9, 2024

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

Main Results:

Demonstrated successful guidance of neurite growth using focused laser light.
Observed light-induced actin accumulations at the neurite's leading edge.
Showed that directed actin growth influences neurite mobility.

Conclusions:

Focused light can precisely guide neurite outgrowth.
Light-mediated control of actin dynamics is a viable strategy for neurite manipulation.
This technique offers potential for neural regeneration and research applications.