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Published on: June 13, 2017
Mitochondrial myopathy: a rare cause of early-onset vocal fold atrophy
Elizabeth A Kelly1, Jonathan M Bock, Amanda C Peltier
1Division of Laryngology and Professional Voice, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Objectives:
We present the second published case of laryngeal involvement in mitochondrial myopathy.
Methods:
A patient with laryngeal involvement of mitochondrial myopathy is presented, together with a literature review.
Results:
A 41-year-old man presented with progressive breathy dysphonia. His brother had mitochondrial myopathy. Biopsy of the biceps muscle demonstrated cytochrome C oxidase-negative ragged blue fibers confirming mitochondrial myopathy. Videostroboscopy showed marked vocal fold atrophy, but subsequent injection laryngoplasty did not significantly improve the patient's voice, despite improved postoperative glottic closure.
Conclusions:
Mitochondrial myopathy should be considered in the differential diagnosis of severe early-onset vocal fold atrophy.
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