Related Experiment Video
Updated: May 12, 2026
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
Thrombospondin in colorectal disease
1Department of Medicine, University of Manchester, Manchester, UK, Department Pathological Sciences, University of Manchester, Manchester, UK, Department of Pathology, University Hospital of South Manchester, Manchester, UK.
Objective:
To assess the presence of thrombospondin (TSP) in normal and colonic disease and correlate its presence to survival in colorectal cancers.
Materials And Methods:
A specific antibody was used to stain paraffin-embedded sections of human colorectal disease (103 carcinomas, 10 inflammatory bowel disease (IBD), 10 diverticulosis and 10 normal). The stained sections were viewed by light microscopy and the degree of staining was quantified using computer-assisted image analysis system.
Results:
Seventy-three percent of carcinomas, 30% of IBD and 80% of the diverticulosis specimens stained for TSP. None of the 'normal' specimens examined showed any staining. No significant correlation could be detected between TSP expression and survival in colorectal cancer patients.
Conclusion:
The presence of TSP in the colon is not specific and merely indicates the presence of a disease process.
Related Concept Videos
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
01:25Inflammatory Bowel Disease III: Crohn's Disease
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
01:27Diverticular Disease of the Colon
01:30Venous Thrombosis I: Introduction
01:24Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.