Related Experiment Video
Updated: May 12, 2026
An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
Abnormal hepatic perfusion index predicts recurrence of colorectal carcinoma
A I Sarela1, H J Gallagher, R C Macadam
1Professorial Surgical Unit, St James's University Hospital, Leeds, UK Department of Medical Physics, St James's University Hospital, Leeds, UK.
Objective:
The hepatic perfusion index (HPI) is a ratio of the gradient of hepatic arterial to total hepatic blood flow. This study correlated HPI with histopathological indicators of prognosis and disease-free survival following curative resection of colorectal cancer.
Patients And Methods:
HPI was measured preoperatively by dynamic hepatic scintigraphy in 37 patients with a primary colorectal cancer and no evidence of distant metastases who underwent a curative resection.
Results:
Abnormally elevated HPI were detected in 49% of patients and were significantly more frequent in association with locally advanced tumours (T3 and T4) in comparison with early tumours (T1 and T2; 59% vs 20%, respectively; P=0.04). There was no association between abnormal HPI and presence of lymph node metastases or degree of tumour differentiation. The 18-month disease-free survival rate of patients with abnormal HPI was significantly shorter than that of patients with normal HPI (53% vs 100%, respectively; P=0.01), and this was independent of the T category.
Conclusion:
HPI predicts the risk of recurrent colorectal carcinoma, and this measurement should be included in the panel of prognostic markers in future clinical trials.
