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Copper-catalyzed decarboxylative coupling of alkynyl carboxylates with 1,1-dibromo-1-alkenes
Zheng Huang1, Rui Shang, Zi-Rong Zhang
1Anhui Province Key Laboratory of Biomass Clean Energy, Collaborative Innovative Center of Chemistry for Energy Materials, and Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China.
Abstract:
A copper-catalyzed decarboxylative coupling reaction of potassium alkynyl carboxylates with 1,1-dibromo-1-alkenes was developed for the synthesis of unsymmetrical 1,3-diyne and 1,3,5-triyne derivatives. Diverse aryl, alkenyl, alkynyl, and alkyl substituted 1,1-dibromo-1-alkenes can react smoothly with aryl and alkyl substituted propiolates to produce unsymmetrical 1,3-diynes and 1,3,5-triynes with high selectivity and good functional group compatibility.
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