Association between obstructive sleep apnea and pulmonary embolism
Alberto Alonso-Fernández1, Mónica de la Peña, David Romero
1Department of Pneumology, University Hospital Son Espases, Palma de Mallorca, Spain. alberto.alonso@ssib.es
Mayo Clinic Proceedings
|April 13, 2013
Summary
Obstructive sleep apnea (OSA) is more common in patients with pulmonary embolism (PE). This study found a significant link between OSA and PE, independent of other risk factors.
Area of Science:
- Cardiology
- Pulmonology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) is a common condition characterized by repeated episodes of upper airway collapse during sleep.
- Pulmonary embolism (PE) is a serious condition caused by a blockage in the pulmonary arteries.
- The relationship between OSA and PE requires further investigation.
Purpose of the Study:
- To compare the prevalence of OSA in patients with PE against a matched control group.
- To determine the association between OSA and PE.
Main Methods:
- A case-control study was conducted between 2006 and 2009.
- 107 patients with PE and 102 controls were included.
- Data collected included medical history, anthropometrics, sleepiness scores, respiratory polygraphy, biochemical profiles, spirometry, and physical activity.
Main Results:
- Patients with PE exhibited a significantly higher apnea-hypopnea index (AHI) compared to controls (21.2 vs 11.5 h(-1)).
- The prevalence of an AHI > 5 h(-1) and hypersomnolence was higher in PE patients.
- Adjusted analysis revealed an odds ratio of 3.7 for PE in patients with OSA (95% CI, 1.3-10.5).
Conclusions:
- OSA is more prevalent in patients diagnosed with acute PE.
- A significant and independent association exists between OSA and PE.
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