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Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 29, 2010
DNA replication: polymerase epsilon as a non-catalytic converter of the helicase
1Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, CB2 1QN, UK. paz20@hermes.cam.ac.uk
Current Biology : CB
|April 13, 2013
Abstract:
In eukaryotes DNA polymerase epsilon (ε) synthesises the leading DNA strand during replication. A new study provides insight into how this polymerase also functions independently of its enzyme activity to assemble and activate the replicative helicase.
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