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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.

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Related Experiment Video

Updated: May 12, 2026

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

Biological rhythms and preeclampsia.

Agnès J Ditisheim1, Charna Dibner, Jacques Philippe

  • 1Hypertension Unit, Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Specialties of Medicine and Primary Care, Hôpitaux Universitaires de Genève Geneva, Switzerland.

Frontiers in Endocrinology
|April 13, 2013
PubMed
Summary
This summary is machine-generated.

Impaired circadian rhythms, common in shift work, are linked to health issues. This review explores if disrupted biological clocks increase preeclampsia risk during pregnancy.

Keywords:
circadian clockpreeclampsiapregnancyshift workwomen health

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Area of Science:

  • Obstetrics and Gynecology
  • Sleep Medicine
  • Cardiovascular Health

Background:

  • Circadian rhythm disruption is linked to cardiovascular disease and cancer.
  • Preeclampsia is a serious pregnancy complication with unclear mechanisms.
  • Shift work in pregnancy is associated with adverse birth outcomes.

Purpose of the Study:

  • To review the circadian patterns of blood pressure in pregnancy.
  • To explore the hypothesis that circadian misalignment is a risk factor for preeclampsia.
  • To investigate the potential link between circadian clock genes and preeclampsia.

Main Methods:

  • Literature review of recent observations.
  • Analysis of circadian blood pressure patterns in normotensive and hypertensive pregnancies.
  • Exploration of existing research on circadian disruption and pregnancy outcomes.

Main Results:

  • Shift work in pregnancy shows a slight increase in risks for small-for-gestational-age, low birth weight, and preterm deliveries.
  • Conflicting results exist regarding the direct link between altered circadian cycles and preeclampsia.
  • Circadian patterns of blood pressure vary between normotensive and hypertensive pregnancies.

Conclusions:

  • Circadian misalignment may be a significant risk factor for preeclampsia.
  • Understanding the circadian clock's role could offer new insights into preeclampsia.
  • Further research is needed to clarify the relationship between circadian rhythms and preeclampsia.