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Updated: May 12, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
Published on: November 22, 2021
Neural bases of hand synergies
Marco Santello1, Gabriel Baud-Bovy, Henrik Jörntell
1Neural Control of Movement Laboratory, School of Biological and Health Systems Engineering, Arizona State University Tempe, AZ, USA.
Abstract:
The human hand has so many degrees of freedom that it may seem impossible to control. A potential solution to this problem is "synergy control" which combines dimensionality reduction with great flexibility. With applicability to a wide range of tasks, this has become a very popular concept. In this review, we describe the evolution of the modern concept using studies of kinematic and force synergies in human hand control, neurophysiology of cortical and spinal neurons, and electromyographic (EMG) activity of hand muscles. We go beyond the often purely descriptive usage of synergy by reviewing the organization of the underlying neuronal circuitry in order to propose mechanistic explanations for various observed synergy phenomena. Finally, we propose a theoretical framework to reconcile important and still debated concepts such as the definitions of "fixed" vs. "flexible" synergies and mechanisms underlying the combination of synergies for hand control.
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