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Related Experiment Video

Updated: May 12, 2026

Measurement of Lifespan in Drosophila melanogaster
10:00

Measurement of Lifespan in Drosophila melanogaster

Published on: January 7, 2013

Indy mutations and Drosophila longevity.

Blanka Rogina1, Stephen L Helfand

  • 1Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center Farmington, CT, USA.

Frontiers in Genetics
|April 13, 2013
PubMed
Summary
This summary is machine-generated.

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Decreasing Indy gene expression in flies and worms boosts longevity. This involves altered metabolism and increased mitochondrial growth, mimicking calorie restriction benefits.

Area of Science:

  • Biochemistry
  • Genetics
  • Aging Research

Background:

  • The Indy gene and its mammalian homolog are transporters of Krebs cycle intermediates, primarily citrate.
  • Cytosolic citrate plays a role in energy regulation, impacting fatty acid synthesis and glycolysis.
  • Indy gene homologs are primarily expressed in tissues crucial for intermediary metabolism.

Purpose of the Study:

  • To investigate the effect of Indy gene expression on longevity.
  • To explore the metabolic and physiological changes associated with decreased Indy expression.
  • To determine if Indy alleles confer increased longevity across diverse genetic backgrounds.

Main Methods:

  • Analyzing Indy gene expression in flies and worms.
  • Examining metabolic changes (lipids, carbohydrates) in organisms with altered Indy expression.
Keywords:
Drosophila melanogasterIndyaging and longevityfruit fliessingle gene mutation

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Related Experiment Videos

Last Updated: May 12, 2026

Measurement of Lifespan in Drosophila melanogaster
10:00

Measurement of Lifespan in Drosophila melanogaster

Published on: January 7, 2013

Methods to Test Endocrine Disruption in Drosophila melanogaster
09:43

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

Endurance Training Protocol and Longitudinal Performance Assays for Drosophila melanogaster
09:49

Endurance Training Protocol and Longitudinal Performance Assays for Drosophila melanogaster

Published on: March 26, 2012

  • Assessing mitochondrial biogenesis in response to decreased Indy function.
  • Evaluating longevity in various genetic backgrounds with different Indy alleles.

    • Main Results:

    • Decreased Indy expression in flies and worms extends lifespan.
    • Reduced Indy function leads to metabolic shifts resembling calorie restriction, including lower lipid levels and altered carbohydrate metabolism.
    • Increased mitochondrial biogenesis was observed with decreased Indy expression.
    • Several Indy alleles were found to confer increased longevity in diverse genetic backgrounds.

    Conclusions:

    • Decreased Indy gene expression is a valid strategy for extending lifespan.
    • The Indy gene is a key regulator of metabolism and aging.
    • Targeting Indy offers a potential pathway for interventions to promote longevity.