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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Understanding phenotypic variation in rodent models with germline Apc mutations.
Maged Zeineldin1, Kristi L Neufeld
1Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
Cancer Research
|April 13, 2013
Summary
Rodent models of the Adenomatous polyposis coli (APC) gene aid colorectal cancer research. This review compares available APC rodent models, explaining variations in intestinal polyps and other phenotypes.
Area of Science:
- Oncology
- Genetics
- Animal Models
Background:
- The Adenomatous polyposis coli (APC) gene is a key tumor suppressor, particularly in colorectal cancer.
- Apc mutations in rodent models are vital for studying cancer development and gene function.
- Over 20 Apc mouse and rat models have been developed since the early 1990s.
Purpose of the Study:
- To compare and contrast existing Apc rodent models.
- To provide explanations for observed variations in these models.
- To focus on intestinal polyp multiplicity, distribution, and extraintestinal phenotypes.
Main Methods:
- Literature review and comparative analysis of published Apc rodent models.
- Examination of genetic alterations and their phenotypic consequences.
- Synthesis of data on polyp formation and extraintestinal manifestations.
Main Results:
- Significant variability exists among Apc rodent models regarding polyp formation and location.
- Extraintestinal phenotypes also display considerable variation across different models.
- Specific Apc mutations correlate with distinct patterns of polyp development and extraintestinal effects.
Conclusions:
- Understanding the nuances of Apc rodent models is crucial for accurate research interpretation.
- The choice of Apc model impacts the study of colorectal cancer and related pathways.
- Further characterization of these models will refine their utility in translational research.
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