Correlations between hepatic monooxygenase system and glycogen storage

In experiments performed on female Wistar rats we have stated that simultaneously with glycogen mobilisation occurring immediately after epinephrine injection the amount of cytochrome P-450 (cP-450) was reduced. A characteristic cP-450 dependent function hexobarbital biotransformation was inhibited. No changes in hepatic protein and water content and serum bilirubin were measured. Glycogen and cP-450 loss and functional impairment depend on the administered epinephrine dose and time of treatment. We have proven that reduced activity of mixed function monooxygenase is related only to diminished glycogen content of the liver. Restitution of glycogen stores as well as amount and function of cP-450 were parallel.