Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum hormone levels affect sperm function.

M T Mbizvo1, S Thomas, D L Fulgham

  • 1Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23510.

Fertility and Sterility
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trichodiene Production in a Trichoderma harzianum erg1-Silenced Strain Provides Evidence of the Importance of the Sterol Biosynthetic Pathway in Inducing Plant Defense-Related Gene Expression.

Molecular plant-microbe interactions : MPMI·2015
Same author

Effects of Trichothecene Production on the Plant Defense Response and Fungal Physiology: Overexpression of the Trichoderma arundinaceum tri4 Gene in T. harzianum.

Applied and environmental microbiology·2015
Same author

Involvement of Trichoderma trichothecenes in the biocontrol activity and induction of plant defense-related genes.

Applied and environmental microbiology·2012
Same author

Identification of loci and functional characterization of trichothecene biosynthesis genes in filamentous fungi of the genus Trichoderma.

Applied and environmental microbiology·2011
Same author

CLM1 of Fusarium graminearum encodes a longiborneol synthase required for culmorin production.

Applied and environmental microbiology·2009
Same author

Morbidity and mortality patterns in HIV-1 seropositive/ seronegative women in Kampala and Harare during pregnancy and in the subsequent two years.

The Central African journal of medicine·2007
Same journal

Confronting complexities of uterus transplantation: Balancing Innovation, Risk and Access.

Fertility and sterility·2026
Same journal

Fertility Benefits and Parental Leave Policies across Accreditation Council for Graduate Medical Education (ACGME) Programs with Ob/Gyn Residency Programs.

Fertility and sterility·2026
Same journal

Optimizing the therapeutic donor insemination cycle.

Fertility and sterility·2026
Same journal

Hormonal and metabolic effects of the administration of oral low-dose 17-β-estradiol (0.2 mg) in patients with Functional Hypothalamic Amenorrhea (FHA): A Retrospective Pilot Study.

Fertility and sterility·2026
Same journal

Biomarker or Bystander? Considering Triglyceride Glucose-Body Mass Index (TyG-BMI) in Patients with Polyendocrine Metabolic Ovarian Syndrome.

Fertility and sterility·2026
Same journal

The Importance of the Incubator: Perinatal Outcomes following Intravaginal Culture.

Fertility and sterility·2026
See all related articles

Hormone levels significantly impact sperm function. Estradiol (E2) enhanced sperm movement and longevity, while progesterone (P) promoted hyperactivation, potentially affecting fertilization success in artificial insemination.

Area of Science:

  • Reproductive biology
  • Sperm physiology
  • Endocrinology

Background:

  • Sperm capacitation is a crucial process for fertilization, influenced by the female reproductive environment.
  • The role of specific hormones, such as estradiol (E2) and progesterone (P), in modulating sperm function during artificial insemination (AI) remains incompletely understood.
  • Understanding these hormonal effects is vital for optimizing AI success rates.

Purpose of the Study:

  • To investigate the impact of women's serum and exogenous hormone preparations (E2 and P) on various sperm functional characteristics.
  • To determine how different hormonal conditions affect sperm motility, velocity, linearity, beat frequency, lateral head displacement, longevity, and hyperactivation.
  • To assess the potential implications for sperm fertilizability in assisted reproductive technologies.

Related Experiment Videos

Main Methods:

  • Sperm specimens were incubated with early follicular phase serum (low E2, low P).
  • Sperm were also incubated with exogenous estradiol (E2) and progesterone (P) preparations.
  • Key sperm functional movement characteristics, including motility, progressive velocity, linearity, beat cross frequency, lateral head displacement, longevity, and hyperactivation, were analyzed.

Main Results:

  • Early follicular phase serum (low E2, low P) effectively maintained sperm motility and longevity.
  • Estradiol (E2)-treated sperm demonstrated significantly enhanced progressive velocity, linear motility, and longevity.
  • Progesterone (P) exposure led to a decrease in percent motility and induced sperm hyperactivation.

Conclusions:

  • Hormonal milieu, particularly estradiol, plays a significant role in regulating sperm motility and function.
  • Estradiol appears beneficial for sperm movement and survival, potentially improving fertilizability.
  • Progesterone's induction of hyperactivation suggests a complex role that may decrease overall motility in certain contexts, impacting AI outcomes.