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Published on: October 2, 2020

Encephalopathy secondary to isoniazid in patients on hemodialysis

M T Abbas1, F Y Khan, S Sulimon

  • 1Department of Medicine, Hamad General Hospital, Doha, Qatar.

Indian Journal of Nephrology
|April 13, 2013
PubMed

We report isoniazid (INH)-induced encephalopathy in two male patients on hemodialysis. One of them had tuberculous adenitis, and the other had pulmonary tuberculosis. Both were given rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine 40 mg/day. Two patients developed disturbances in consciousness. After excluding other causes, INH-induced encephalopathy was suspected so the drug was stopped and dose of pyridoxine increased. Both patients retained their consciousness within 1 week and were discharged.

Keywords:
Encephalopathyend-stage renal failuretuberculosis

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