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Published on: September 29, 2019
S100B protein in tissue development, repair and regeneration
Guglielmo Sorci1, Francesca Riuzzi, Cataldo Arcuri
1Guglielmo Sorci, Francesca Riuzzi, Cataldo Arcuri, Claudia Tubaro, Roberta Bianchi, Ileana Giambanco, Rosario Donato, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy.
World Journal of Biological Chemistry
|April 13, 2013
Summary
The S100B protein regulates cellular functions both inside and outside cells. Extracellular S100B promotes tissue repair and homeostasis in the nervous system and muscle.
Area of Science:
- Biochemistry
- Cell Biology
- Neuroscience
Background:
- S100B is a calcium-binding protein with diverse intracellular roles.
- Extracellular S100B acts as a signaling molecule, interacting with receptors like RAGE.
Purpose of the Study:
- To summarize the intracellular and extracellular regulatory functions of S100B.
- To highlight S100B's role in tissue development, repair, and regeneration.
Main Methods:
- Literature review and synthesis of existing research on S100B.
- Analysis of S100B's interactions with various proteins and receptors.
Main Results:
- Intracellular S100B regulates metabolism, transcription, proliferation, and Ca(2+) homeostasis.
- Extracellular S100B, particularly at low nM concentrations, promotes trophic effects in neural and muscle tissues.
- S100B signaling involves RAGE and potentially enhances FGF signaling.
Conclusions:
- S100B plays critical roles in both intracellular processes and extracellular signaling.
- Extracellular S100B is crucial for tissue homeostasis, repair, and regeneration.
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