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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
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Protein quality control and cancerogenesis

F Trcka1, B Vojtesek, P Muller

  • 1Regional Centre for Applied and Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
|April 13, 2013
PubMed

Insights

Cellular protein quality control is vital for preventing damage and maintaining homeostasis. This review explores how these essential protein quality control pathways function in cancer cells.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Oncology

Background:

  • Nascent and mature proteins are susceptible to damage from internal and external factors.
  • Misfolded proteins pose physiological risks within the cell and require efficient elimination.
  • Eukaryotic cells possess sophisticated protein quality control (PQC) systems to maintain protein homeostasis.

Purpose of the Study:

  • To review the three major protein quality control pathways.
  • To elucidate the specific roles of PQC in cancer cells.
  • To understand the implications of PQC in cancer development and progression.

Main Methods:

  • Literature review of protein quality control mechanisms.
  • Analysis of PQC pathway involvement in cancer biology.
  • Discussion of PQC regulation in tumor microenvironments.

Main Results:

  • Cancer cells exhibit increased production of damaged and deregulated proteins due to genetic instability.
  • The tumor microenvironment imposes unique challenges on PQC machineries.
  • PQC pathways are critical for regulating protein turnover and degrading tumor-promoting/suppressing proteins.

Conclusions:

  • Protein quality control is indispensable for managing cellular proteostasis, particularly in the context of cancer.
  • Dysregulation of PQC contributes significantly to cancer development and progression.
  • Targeting PQC pathways presents a potential therapeutic strategy for cancer treatment.

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