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Replicate differences in lines of mice selected for body composition.

E J Eisen1, D Pomp

  • 1Department of Animal Science, North Carolina State University, Raleigh 27695-7621.

Genome
|April 1, 1990
PubMed
Summary

Genetic selection for fat and carcass weight in mice revealed significant genetic drift but minimal differences between selected and control lines. Heterosis effects were observed in selected lines, but were small relative to overall divergence.

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Area of Science:

  • Animal Genetics
  • Quantitative Genetics
  • Physiological Genetics

Background:

  • Mice lines were divergently selected for body composition traits.
  • Understanding genetic drift and heterosis is crucial for animal breeding programs.

Purpose of the Study:

  • To investigate genetic drift and heterosis in mice selected for body composition.
  • To analyze divergence between selected and control lines.

Main Methods:

  • Selection for high/low epididymal fat pad weight (%EFP) and hind carcass weight (%HC).
  • Analysis of correlated traits including subcutaneous fat pad weight (%SFP) and water content (%WAT).
  • Multivariate analyses (discriminant function, Mahalanobis distance) to assess divergence.

Main Results:

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  • Individual and maternal effects caused significant genetic drift in selected and correlated traits.
  • No evidence of greater drift in selection treatments compared to controls.
  • Significant heterosis observed for %HC and %EFP in specific selected lines, but not in control crosses.
  • Divergence between parental lines and replicate crosses was similar, with small heterosis differences.
  • Asymmetry in heterosis was greater between replicate crosses and parental lines.

Conclusions:

  • Divergence within selection treatments was minimal compared to divergence among selection treatments.
  • Selected replicates showed greater average heterosis than control replicates.
  • Genetic drift and heterosis play roles in the divergence of selected mouse lines for body composition.