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Related Experiment Video

Updated: May 12, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

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Resynchronization: considering device-based cardiac therapy in older adults.

Daniel B Kramer1, Matthew R Reynolds, Susan L Mitchell

  • 1Hebrew Senior Life Institute for Aging Research, Boston, MA 02215, USA. danielkramer@hsl.harvard.edu

Journal of the American Geriatrics Society
|April 16, 2013
PubMed
Summary

Cardiac resynchronization therapy (CRT) offers benefits for heart failure (HF) patients, but its use in older adults requires careful consideration due to potential complications and unique outcomes. More research is needed for informed decision-making in this growing population.

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Area of Science:

  • Cardiology
  • Geriatrics
  • Medical Device Technology

Background:

  • Cardiac resynchronization therapy (CRT) is a device-based treatment for systolic heart failure (HF).
  • A significant proportion of HF patients receiving CRT are aged 65 and older.
  • Shifting demographics and expanded indications necessitate understanding CRT in older adults.

Purpose of the Study:

  • To review the current knowledge regarding the use and outcomes of CRT specifically in older adults (aged 65+).
  • To identify gaps in understanding concerning CRT benefits, risks, and patient-centered outcomes in the elderly population.
  • To inform clinicians, policymakers, and patients for better decision-making regarding CRT in older individuals.

Main Methods:

  • Review of existing clinical trials and studies on Cardiac Resynchronization Therapy (CRT).
  • Analysis of data concerning CRT efficacy and safety in elderly populations (65+).
  • Evaluation of how well current trials capture outcomes relevant to older adults, such as quality of life and end-of-life care.

Main Results:

  • Generalizability of CRT benefits from clinical trials to older adults is uncertain.
  • Device-related complications may be more frequent with CRT and in older patients.
  • Existing CRT trials may not adequately assess outcomes critical to older adults.

Conclusions:

  • Further research is essential to understand the specific use and outcomes of CRT in older adults.
  • Enhanced understanding is crucial for informed clinical decision-making, policy development, and patient engagement.
  • Addressing quality of life and end-of-life care is vital when considering CRT for the elderly.