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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

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Related Experiment Video

Updated: May 12, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

Blastic plasmacytoid dendritic cell neoplasm.

David Lim1, Hugh Goodman, Marius Rademaker

  • 1Department of Dermatology, Waikato Hospital, Hamilton, Waikato, New Zealand. davidlim79@gmail.com

The Australasian Journal of Dermatology
|April 16, 2013
PubMed
Summary
This summary is machine-generated.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare cancer. This case highlights a 79-year-old man with skin-limited BPDCN progressing to leukemia.

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Published on: March 17, 2014

Related Experiment Videos

Last Updated: May 12, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy.
  • It originates from plasmacytoid dendritic cell precursors.
  • BPDCN often presents with skin manifestations and can progress to a leukemic phase.

Observation:

  • A 79-year-old male presented with a 6-month history of asymptomatic, progressive skin manifestations.
  • The patient's condition was initially limited to the skin.

Findings:

  • The patient was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN).
  • The BPDCN initially presented as skin-limited disease.
  • The neoplasm subsequently progressed to a leukemic phase.

Implications:

  • This case underscores the importance of recognizing BPDCN skin manifestations.
  • Early diagnosis and management are crucial for patients with BPDCN.
  • Understanding disease progression is vital for treatment strategies in this rare malignancy.