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Association between CD14 gene polymorphism and periodontitis: a meta-analysis.

Jingjing Zheng¹, Tiezhou Hou, Ling Gao

¹Department of Endodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.

Critical Reviews in Eukaryotic Gene Expression

|April 16, 2013

Summary

This meta-analysis found no significant link between CD14 C-159T and C-260T gene variations and periodontitis risk. Further research is needed on genetic networks influencing periodontitis susceptibility.

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Area of Science:

Genetics
Periodontology
Molecular Biology

Background:

Periodontitis is a common inflammatory disease affecting the gums.
CD14 gene polymorphisms have been investigated for their potential role in periodontitis susceptibility.
Previous studies on CD14 C-159T and C-260T polymorphisms and periodontitis risk have yielded conflicting results.

Purpose of the Study:

To conduct a meta-analysis evaluating the association between CD14 C-159T and C-260T polymorphisms and periodontitis risk.
To resolve discrepancies in existing literature regarding this genetic association.

Main Methods:

A systematic search identified 12 eligible case-control studies.
Data from 1435 cases and 1446 controls were pooled for meta-analysis.
Subgroup analyses were performed based on ethnicity and periodontitis type.

Main Results:

No significant association was found between CD14 C-159T and C-260T polymorphisms (T alleles, CT/TT genotypes) and overall periodontitis risk.
Subgroup analyses by ethnicity and periodontitis type also revealed no significant associations.
A potential enhanced risk was observed for the C-260T genotype (CT vs. CC), though overall significance was lacking.

Conclusions:

The common CD14 C-159T and C-260T polymorphisms are not significantly associated with periodontitis risk.
Genetic networks and pathway interactions within the CD14 signaling pathway require further investigation for their role in periodontitis susceptibility.