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Related Concept Videos

Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

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Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
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[Hypothyroidism after operation for struma ovarii].

Marjoes Zikkenheimer1, Jens Hertz

  • 1Kirurgisk Afdeling, Bispebjerg Hospital, Denmark. mzikkenheimer@hotmail.com

Ugeskrift for Laeger
|April 16, 2013
PubMed
Summary

Struma ovarii, a rare ovarian tumor, is typically asymptomatic but can cause hyperthyroidism. Post-surgical hypothyroidism necessitates thyroid function monitoring.

Area of Science:

  • Gynecology
  • Endocrinology
  • Pathology

Background:

  • Struma ovarii is a rare germ cell tumor, defined by thyroid tissue comprising over 50% of the ovarian mass.
  • Often found within mature cystic teratomas (dermoid cysts), it is frequently discovered incidentally during pelvic examinations or imaging.
  • While typically asymptomatic, struma ovarii can present with symptoms mimicking other ovarian neoplasms.

Observation:

  • Approximately 5% of patients with struma ovarii may exhibit clinical or biochemical signs of hyperthyroidism or thyrotoxicosis.
  • The presented case highlights a patient who developed biochemical hypothyroidism following surgical resection of the struma ovarii.
  • This observation underscores the potential for thyroid dysfunction, both pre- and post-operatively.

Findings:

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  • Surgical removal is the standard treatment for struma ovarii.
  • Post-operative thyroid function assessment is crucial, as demonstrated by the case of induced hypothyroidism.
  • The thyroid tissue within the tumor can influence systemic thyroid hormone levels.

Implications:

  • Patients diagnosed with struma ovarii require careful pre- and post-operative thyroid function evaluation.
  • Endocrinological monitoring is essential to manage potential thyroid imbalances after treatment.
  • This case emphasizes the importance of considering thyroid function in the management of ovarian teratomas.