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Updated: May 12, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

[Tako-Tsubo cardiomyopathy].

Nicolas Mansencal¹, Olivier Dubourg

¹Assistance publique-Hôpitaux de Paris (AP-HP), hôpital Ambroise-Paré, centre de référence pour les maladies cardiaques héréditaires, université de Versailles-Saint-Quentin (UVSQ), pôle V thorax vasculaire digestif métabolisme, 92100 Boulogne, France. nicolas.mansencal@apr.aphp.fr

Presse Medicale (Paris, France : 1983)

|April 16, 2013

Summary

This summary is machine-generated.

Tako-Tsubo cardiomyopathy, a transient left ventricular dysfunction, often mimics heart attacks and primarily affects postmenopausal women. Diagnosis relies on specific criteria and imaging, with full recovery being the typical outcome.

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Last Updated: May 12, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Area of Science:

Cardiology
Internal Medicine

Context:

Tako-Tsubo cardiomyopathy (TTC) presents as a transient left ventricular systolic dysfunction, often mimicking acute coronary syndromes.
While stress is a common trigger, it is not universally present in all cases.

Purpose:

To outline the diagnostic criteria and assessment methods for Tako-Tsubo cardiomyopathy.
To describe the typical presentation, affected demographic, and expected prognosis of TTC.

Summary:

Diagnosis is established using the Mayo Clinic criteria, involving electrocardiogram, biomarkers, echocardiography, coronary angiography, and cardiac MRI.
The hallmark finding is transient left ventricular dysfunction with characteristic apical and mid-ventricular akinesia.
Potential acute complications require systematic evaluation.

Impact:

Understanding TTC's diagnostic pathway and characteristic features aids in accurate identification and management.
Recognizing the typical complete recovery of left ventricular function confirms the diagnosis and guides follow-up care.