Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control
Jeffrey S Mugridge1, John D Gross
1Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Molecular Cell
|April 16, 2013
Abstract:
In this issue of Molecular Cell, Jiao et al. (2013) describe the mammalian enzyme DXO, which has pyrophosphohydrolase, decapping, and 5'-3' exoribonuclease activity and functions as an important checkpoint in cotranscriptional capping of RNA polymerase II (Pol II) pre-mRNA transcripts.
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