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Related Experiment Video

Updated: May 12, 2026

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
07:55

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Published on: June 21, 2019

Microtools for single-cell analysis in biopharmaceutical development and manufacturing.

Kerry Routenberg Love1, Sangram Bagh, Jonghoon Choi

  • 1The David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Trends in Biotechnology
|April 16, 2013
PubMed
Summary

Microtools for single-cell analysis can accelerate biopharmaceutical development. These technologies address challenges in biologic drug similarity, toxicity, and accessibility, potentially reducing costs and time to market.

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Area of Science:

  • Biopharmaceutical industry
  • Drug development
  • Biotechnology

Background:

  • Biologic drugs are driving growth in the biopharmaceutical sector.
  • Significant time and costs are associated with bringing new biologics to market.
  • Key challenges include establishing product similarity, assessing toxicity, and ensuring global accessibility.

Purpose of the Study:

  • To explore the potential of microtools in addressing challenges in biologic drug development.
  • To highlight recent examples of microtools with applications in this field.
  • To discuss how integrating these technologies can impact biologic drug development timelines and costs.

Main Methods:

  • Review of recent advancements in microtool technology for single-cell isolation and interrogation.

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Last Updated: May 12, 2026

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells
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Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Published on: June 21, 2019

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
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  • Analysis of the demonstrated or potential utility of these microtools in addressing specific biologic drug development challenges.
  • Consideration of the integration of microtools into existing biologic drug development workflows.

    • Main Results:

    • Microtools offer novel approaches for establishing product similarity.
    • Single-cell interrogation tools can aid in the assessment of product toxicity.
    • Enhanced cell isolation techniques may improve the efficiency of developing globally accessible biologics.

    Conclusions:

    • Microtools show significant promise for overcoming critical hurdles in biologic drug development.
    • The integration of advanced microtechnologies can substantially reduce development time and costs.
    • Wider adoption of these tools could lead to increased global availability of biologic therapies.